실크 피브로인 나노 차폐막(나노가이드-에스)을 이용한 치조골 유도재생능력에 관한 비교 연구
A comparative study for guided bone regeneration of silk fibroin nanomembrane(NanoGide-STM)
한대현, 홍기석, 정진형, 임성빈,
소속 상세정보
한대현 ( Han Dae-Hyun ) - 단국대학교 치과대학 치주과학교실
홍기석 ( Hong Ki-Seok ) - 단국대학교 치과대학 치주과학교실
정진형 ( Chung Chin-Hyung ) - 단국대학교 치과대학 치주과학교실
임성빈 ( Lim Sung-Bin ) - 단국대학교 치과대학 치주과학교실
KMID : 0363020080380030475
Abstract
Purpose: To evaluate the safety and efficiency of bone regenerative abilities of silk fibroin nanomembrane(Nanoguide-S)
Material and Methods: The objects were 38 patients who had large defect at extraction sockets caused by chronic periodontitis and silk fibroin nano matrix were used on experimental group(N=19) and PLA/PLGA matrix were used on control group(N=19). The width, height, and length by crown-apical direction(socket depth) of defects were measured with the occlusal plane as a reference plane, and tooth axis direction, perpendicular to tooth axis direction were measured on radiographs at 3 months pre-operative, 3 months post-operative.
Result: Tissue response to silk fibroin nano matrix and Biomesh were clinically satisfactory and complications such as swelling, exudation, ulceration and vesicles were not found except the ordinary discomfort of operated portion. 3 months later, the width, height, and length by crown-apical direction (socket depth) of defects were clinically improved in both groups with no significant difference. 3 months later radiolucency of tooth axis direction and perpendicular to tooth axis direction were all increased in both groups with no significant difference.
Conclusion: By these results biodegradadable silk fibroin nano matrix was efficient in GBR on alveolar bone resorption caused by periodontitis compared to Biomesh.
키워드
Silk fibroin nanomembrane;guided bone regeneration
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